Publications

Roe, C.M., Stout, S.H., Rajasekar, G., Ances, B.M., Head, D.M., Benzinger, T.L.S., Williams, M.M., Davis, J.D., Ott, B.R., Warren, D.K., Babulal, G.M. (2019). A 2.5 Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer Disease. Journal of Alzheimer’s Disease 68(4), 1625-1633.

Babulal, G.M., Quiroz, Y.T., Albensi, B.C., Arezana-Urquijo, E., Astell, A.J., Babiloni, C., Bahar-Fuchs, A., Bell, J., Bowman, G.L., Brickman, A.M., Cheltelat, G., Ciro, C., Cohen, A.D., Dilworth-Anderson, P., Dodge, H.H., Dreux, S., Edland, S., Esbensen, A., Evered, L., Ewers, M., Fargo, K.N., Fortea, J., Gonzalez, H., Gustafson, D.R., Head, E., Hendrix, J.A., Hofer, S.M., Johnson, L.A., Jutten, R., Kilborn, K., Lanctot, K.L., Manly, J.J., Martins, R.N., Mielke, M.M., Morris, M.C., Murray, M.E., Oh, E.S., Parra, M.A., Rissman, R.A., Roe, C.M., Santos, O.A., Scarmeas, N., Schneider, L.S., Schupf, N., Sikkes, S., Snyder, H.M., Sohrabi, H.R., Stern, Y., Strydom, A., Tang, Y., Terrera, G.M., Teunissen, C., van Lent, D.M., Weinborn, M., Wesselman, L., Wilcock, D.M., Zetterberg, H., O’Bryant, S.E. Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: Update and areas of immediate need. (2018). Alzheimer’s & Dementia.

Babulal, G.M., Chen, S., Williams, M.M., Trani, J.F., Bakhshi, P., Chao, G.L., Stout, S., Fagan, A.M., Benzinger, T.L.S., Holtzman, D.M., Morris, J.C., Roe, C.M. Depression and Alzheimer disease biomarkers predict driving decline. (2018). Journal of Alzheimer’s Disease. 66(3).

Roe, C.M., Ances, B.M., Head, D., Babulal, G.M., Stout, S.H., Grant, E.A., Xiong, C., Holtzman, D.M., Benzinger, T.L.S., Fagan, A.M., & Morris, J.C. (2018). Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain. https://doi.org/10.1093/brain/awy244

Roe, C. M., Babulal, G. M., Stout, S. H., Carr, D. B., Williams, M. M., Benzinger, T. L., … & Morris, J. C. (2018). Using the A/T/N Framework to Examine Driving in Preclinical Alzheimer’s Disease. Geriatrics3(2), 23.

Babulal, G.M., Williams, M.M., Stout, S.H., & Roe, C.M. (2018). Driving outcomes among older adults: A systematic review on racial and ethnic differences over 20 years. Geriatrics. 3(1), 12; doi:10.3390/geriatrics3010012

Allison, S., Babulal, G. M., Stout, S. H., Barco, P. P., Carr, D. B., Fagan, A. M., … & Head, D. (2018). Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults. Alzheimer Disease & Associated Disorders32(2), 101-106.

Stout, S. H., Babulal, G. M., Ma, C., Carr, D. B., Head, D. M., Grant, E. A., … & Roe, C. M. Driving cessation over a 22-year period: Dementia severity and CSF biomarkers. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. (2018);13:7, P1207-P1208.

Gabel M, Gooblar J, Roe CM, Selsor NJ, Morris JCM. Political ideology, confidence in science, and participation in clinical research. Alzheimer’s Disease and Associated Disorders (2018).

Day, G. S., Lim, T. S., Hassenstab, J., Goate, A. M., Grant, E. A., Roe, C. M., … & Morris, J. C. (2017). Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease. Neurology. 2017;88;13:1273-1281.

Babulal GM, Stout SH, Head D, Holtzman DM, Fagan AM, Morris JC, Roe CM. (2017). Neuropsychiatric symptoms and alzheimer’s disease biomarkers predict driving decline: brief report. Journal of Alzheimer’s Disease. 2017;58:3:675-680.

Babulal GM, Stout SH, Head DM, Fagan AM, Benzinger TLS, Ott BR, Carr DB, Webb M, Traub CM, Addison A, Holtzman DM, Morris JC, Warren DK, Roe CM. A naturalistic study of driving behavior in older adults and preclinical Alzheimer disease: A pilot study. Journal of Applied Gerontology. 2017. (doi: 10.1177/0733464817690679)

Roe CM, Babulal GM, Head DM, Stout SH, Vernon EK, Ghoshal N, Garland B, Barco PP, Williams MW, Johnson A, Fierberg R, Fague MS, Xiong C, Mormino E, Grant EA, Holtzman DM, Benzinger TLS, Fagan AM, Ott BR, Carr DB, Morris JC. Preclinical Alzheimer Disease and Longitudinal Driving Decline. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2017;3:74-82. (doi: 1016/j.trci.2016.11.006)

Ott BR, Jones RN, Noto RB, Yoo DC, Snyder PJ, Bernier JN, Carr DB, Roe CM. Brain amyloid in preclinical Alzheimer’s disease is associated with increased driving risk. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016;6:136-142. (doi:1016/j.dadm.2016.10.008)

Babulal GM, Traub CM, Webb M, Stout SH, Addison A, Carr DB, Ott BR, Morris JC, Roe CM. Creating a driving profile for older adults using GPS devices and naturalistic driving methodology [version 2; referees: 3 approved]. F1000Research. 2016;5:2376 (doi:12688/f1000research.9608.2)

Carr DB, Barco PP, Babulal GM, Stout SH, Johnson AM, Xiong C, Morris JC, Roe CM. Association of Functional Impairments and Co-Morbid Conditions with Driving Performance among Cognitively Normal Older Adults. PLoS ONE. 2016;11:12:e0167751. (doi: 0.1371/journal. pone.0167751)

Babulal, G.M., Addison, A., Ghoshal, N., Stout S.H., Vernon, E.K., Sellan, M. & Roe, C.M. (2016). Development and interval testing of a naturalistic driving methodology to evaluate driving behavior in clinical research. F1000Research. 5:1716

Babulal, GM, Ghoshal, N, Head, D, Vernon, EK, Holtzman, DM, Benzinger, TL, Fagan, AF, Morris, JC & Roe, CM. Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer’s Disease Biomarker Levels. The American Journal of Geriatric Psychiatry. 2016;24:11:1095-1104.

Roe, CM, Barco, PP, Head, DM, Ghoshal, N, Selsor, N, Babulal, GM, Fierberg R, Vernon, EK, Shulman, N, Johnson, A, Fague, S, Xiong, C, Grant, EA, Ott, BR, Holtzman, DM, Benzinger, TL, Fagan, AM, Carr, DB, Morris, JC. Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals. Alzheimer disease and associated disorders. 2016;31:1:69-72.

Ingber AP, Hassenstab J, Fagan AM, Benzinger TLS, Grant EA, Holtzman DM, Morris JC, Roe CM. Cerebrospinal fluid biomarkers and reserve variables as predictors of future “non-cognitive” outcomes of Alzheimer disease. Journal of Alzheimer’s Disease 2016;52:1055-1064.

Gooblar J, Roe CM, Selsor, NJ, Gabel M, Morris JC. Attitudes of research participants and the general public regarding disclosure of Alzheimer disease research results. JAMA Neurology 2015;72:1484-1490.

Hassenstab J, Monsell SE, Mock C, Roe CM, Cairns NJ, Morris JC, Kukull W. Neuropsychological markers of cognitive decline in persons with Alzheimer’s disease neuropathology. Journal of Neuropathology and Experimental Neurology 2015;74:1086-1092.

Masters MC, Morris JC, Roe CM. “Noncognitive” symptoms of early Alzheimer disease. A longitudinal analysis. Neurology 2015;84:617-622.

Gordon BA, Wang Q, Najmi S, Hsu P, Roe CM, Morris JC, Benzinger TLS. The effects of white matter damage and amyloid deposition on cognition. NeuroImage: Clinical 2015;8:246-252. PMCID: PMC4474174.

Shim YS, Yang D-W, Roe CM, Coats MA, Benzinger TL, Xiong C, Galvin JE, Cairns NJ, Morris JC. Pathological correlates of white matter hyperintensities on magnetic resonance imaging.  Dementia and Geriatric Cognitive Disorders 2015;39:92-104. PMCID: PMC4312498.

Chung EJ, Babulal GM, Monsell SE, Cairns NJ, Roe CM, Morris JC.  Clinical features of Alzheimer disease with and without Lewy bodies. JAMA Neurology 2015;72:789-796. PMCID: PMC4501861.

Vernon EK, Babulal GM, Head, D, Carr, DB, Ghoshal N, Barco P, Morris JC, & Roe CM.  Older adults, ages 65 and older, use potentially distracting electronic devices while driving. Journal of the American Geriatrics Society 2015;63:1251-1253.

Ponce DE, Salech F, Martin CS, Silva ME, Xiong C, Roe CM, Henriquez M, Quest FA, Behrens IM. Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity. Current Alzheimer Research 2014;11:892-898. PMCID: PMC4378649.

Wang L, Day J, Roe CM, Brier MR, Thomas JB, Benzinger TL, Morris JC, Ances BM. The Effect of APOE ε4 Allele on Cholinesterase Inhibitors in Patients with Alzheimer Disease: Evaluation of the Feasibility of Resting State Functional Connectivity Magnetic Resonance Imaging. Alzheimer Disease & Associated Disorders 2014:122-127. PMCID: PMC4024181.

Monsell SE, Mock C, Hassenstab J, Roe CM, Cairns NJ, Morris JC, Kukull W. Neuropsychological changes in asymptomatic persons with Alzheimer’s disease neuropathology. Neurology 2014;83:434-440. PMCID: PMC4132573.

Pizzie R, Hindman H, Roe CM, Head D, Grant E, Morris JC, Hassenstab JJ. Physical Activity and Cognitive Trajectories in Cognitively Normal Aduts: The Adult Children Study. Alzheimer’s Disease & Associated Disorders 2014; 28:50-57. PMCID: PMC3778080.

Shim YS, Roe CM, Buckles V, Morris JC. Clinicopathologic Study of Alzheimer’s Disease: Alzheimer mimics. Journal of Alzheimer’s Disease 2013; 35:799-811. PMCID: PMC3725959.

Monsell SE, Mock C, Roe CM, Ghoshal N, Morris JC, Cairns NJ, Kukull. Comparison of symptomatic and asymptomatic persons with Alzheimer’s disease neuropathology. Neurology 2013;80:2121-2129. PMCID: PMC3716351.

Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, Sutphen CL, Benzinger TLS, Mintun MA, Holtzman DM, Morris JC. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology 2013;80:1784–1791. PMCID: PMC3719431.

Wilkins CH, Roe CM, Morris JC, Galvin JE. Mild Physical Impairment Predicts Future Diagnosis of Dementia of the Alzheimer Type. Journal of the American Geriatrics Society 2013;61:1055-1059. PMCID: PMC3823812.

Obermann KR, Morris JC, Roe CM. Exploration of 100 commonly used drugs and supplements on cognition in older adults. Alzheimer’s & Dementia 2013;9:724-732. PMCID: PMC3823812.

Williams MM, Storandt M, Roe CM, Morris JC. Progression of Alzheimer Dementia as Measured by Clinical Dementia Rating Sum of Boxes Scores. Alzheimer’s & Dementia 2013;9(1 Suppl):S39-44. PMCID: PMC3660405.

Wang L, Roe CM, Snyder AZ, Brier MR, Thomas JB, Xiong C, Benzinger TL, Morris JC, Ances BM. Alzheimer’s disease family history impacts resting state functional connectivity. Annals of Neurology 2012; 72:571-577. PMCID: PMC3490438

Behrens MI, Silva M, Salech F, Ponce DP, Merino D, Sinning M, Xiong C, Roe CM, Quest AF. Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer’s patients and skin cancer survivors: increased apoptosis in Alzheimer’s and reduced necrosis in cancer. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2012;67(10):1036-40. PMCID: PMC3437969

Yang YH, Roe CM, Morris JC. Relationships between late-life hypertension, blood pressure, and Alzheimer’s disease. American Journal of Alzheimers Disease & Other Dementias 2011:457-462. PMCID: PMC3312309.

Xiong C, Roe CM, Buckles V, Fagan AM, Holtzman D, Balota D, Duchek J, Storandt M, Mintun M, Grant E, Head D, Benzinger T, Csernansky J, Morris J. Family history of Alzheimer disease influences biomarker abnormalities in the Adult Children Study.  Archives of Neurology. 2011 Oct; 68(10):1313-9.  NIHMS 333549.

Roe CM, Fagan AM, Grant EA, Marcus DS, Benzinger TLS, Mintun MA, Holtzman DM, Morris JC. Cerebrospinal fluid biomarkers, education, brain volume, and future cognition. Archives of Neurology 2011;68:1145-1152. PMCID: PMC3203689.

Roe CM, Fagan AM, Williams MM, Ghoshal N, Aeschleman M, Grant EA, Marcus DS, Mintun MA, Holtzman DM, Morris JC. Improving CSF Biomarker Accuracy in Predicting Prevalent and Incident Alzheimer’s Disease. Neurology 2011;76(6):501-510. PMCID: PMC3053181.

Perrin RJ, Craig-Shapiro R, Malone JP, Shah AR, Gilmore P, Davis AE, Roe CM, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, Kaye JA, Morris JC, Holtzman DM, Townsend RR, Fagan AM.  Identification and validation of novel cerebrospinal fluid biomarkers of staging early Alzheimer’s disease.  PLoS ONE 2011; 6:e16032 PMCID: PMC3020224

Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Grant EA, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D’Angelo G, Malone JP, Townsend RR, Morris JC, Fagan AM, Holtzman DM. YKL-40: A Novel Diagnostic and Prognostic Fluid Biomarker for Preclinical and Early Alzheimer’s Disease.  Biological Psychiatry 2010;68(10):903-912.

Kinnunen PJ, Tavares AR, de Melo AC, Sternberg C, Burke WJ, Roe CM, Morris JC, Fitzpatrick AL, Behrens MI, Bennett DA. Cancer linked to Alzheimer disease but not vascular dementia. Neurology 2010;75:1215-1217. PMC Journal – In Process.

Roe CM, Mintun MA, Ghoshal N, Williams MM, Grant EA, Marcus DS, Morris JC.  Enhanced identification of Alzheimer’s disease using amyloid imaging: proof of concept. Neurology 2010;75:42-48. PMCID: PMC2906402.

Behrens MI, Roe CM, Quest FG, Morris JC.  Is there a link between dementia and cancer?  Aging Health 2010;6:361-364.

Dreyfus DM, Roe CM, Morris JC. Autobiographical memory task in assessing dementia. Archives of Neurology 2010;67:862-866.

Palmer JL, Coats M, Roe CM, Xiong C, Hanko SM, Morris JC. Advance Practice Nurse and Neurologist Agreement on the United Parkinson’s Disease Rating Scale and Physical/ Neurological Exam. Journal of Advanced Nursing 2010;66:1382-1387. PMCID: PMC2903978.

Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE genotype predicts Aβ but not tau pathology in cognitively normal aging: amyloid imaging and CSF biomarkers in preclinical Alzheimer’s disease. Annals of Neurology 2010;67:122-131. PMCID: PMC2830375

Roe CM, Fitzpatrick AL, Xiong C, Sieh W, Kuller L, Miller JP, Williams MM, Kopan R, Behrens MI, Morris JC. Cancer linked to Alzheimer’s disease but not vascular dementia. Neurology 2010;74:106-112. PMCID: PMC2809029

Wilkins CH, Roe CM, Morris JC. A brief clinical tool to assess physical function in mild dementia: the Mini-PPT. Archives of Gerontology and Geriatrics 2010;50:96-100.

Harper P, Roe CM.  Thyroid disease medication and subsequent development of dementia of the Alzheimer type. Journal Geriatric Psychiatry and Neurology 2010;23:63-69.

Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC, Holtzman DM. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition: implications for future clinical trials of Alzheimer’s disease. EMBO Molecular Medicine 2009;1:371-380. PMCID: PMC2806678

Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. PIB Imaging Predicts Progression to Symptomatic Alzheimer’s Disease. Archives of Neurology 2009;66:1469-1475.

Price JL, McKeel Jr DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen PC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiology of Aging 2009;30:1026-1036. PMCID: PMC2737680

Williams MM, Roe CM, Morris JC. Stability of the Clinical Dementia Rating: 1979-2007. Archives of Neurology 2009;66:773-777. PMCID: PMC2779108

Behrens MI, Lendon C, Roe CM. A common biological mechanism in cancer and Alzheimer’s disease? Current Alzheimer Research 2009:6:196-204. PMCID: PMC2810550

Snider BJ, Fagan AM, Roe C, Shah AR, Grant EA, Xiong C, Morris JC, Holtzman DM. CSF biomarkers predict rate of cognitive decline in very mild dementia of the Alzheimer’s type. Archives of Neurology 2009;66:638-645. PMCID: PMC2759394

Roe CM, Mintun MA, D’Angelo G, Xiong C, Grant E, Morris JC. Alzheimer’s and cognitive reserve: variation of education effect with carbon 11-labled Pittsburgh Compound B. Archives of Neurology 2008;65:1467-1471. PMCID: PMC2752218

Roe CM, Xiong C, Miller JP, Cairns NJ, Morris JC. Interaction of neuritic plaques and education predicts dementia. Alzheimer Disease and Associated Disorders 2008;22:188-193. PMCID: PMC2770714

Roe CM, Xiong C, Grant E, Miller JP, Morris JC. Education and reported onset of symptoms among individuals with Alzheimer’s disease.  Archives of Neurology 2008;65:108-111. PMCID: PMC2830808

Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Medication use as a confounding factor in the use of the cerebrospinal fluid tau/-amyloid42 ratio—reply. Archives of Neurology 2007;64:1357 – 1359.

Khandelwal A, Chandu D, Roe CM, Kopan R, Quatrano RS. Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved. Proceedings of the National Academy of Science USA 2007;104:13337-13342.

Galvin JE, Roe CM, Morris JC. Patient’s rating of cognitive ability: using the AD8, a brief informant interview as a self rating tool to detect dementia. Archives of Neurology 2007;64:725-730.

Galvin JE, Roe CM, Morris JC. Evaluation of cognitive impairment in the older adult: combining brief informant and performance measures.  Archives of Neurology 2007;64:718-724.

Roe CM, Xiong C, Miller JP, Morris JC. Education and Alzheimer’s disease without dementia: support for the Cognitive Reserve Hypothesis. Neurology 2007;68:223-228.

Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid biomarkers of early stage Alzheimer’s disease predict future dementia in cognitively normal older adults. Archives of Neurology 2007;64:343-349.

Galvin JE, Roe CM, Xiong C, Morris JC. The validity and reliability of the AD8.  Neurology 2006;67:1942-1948.

Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency associated with low mood and worse cognitive performance in older adults. American Journal of Geriatric Psychiatry 2006;14:1032-1040.

Galvin JE, Roe CM, Powlishta KK, Coats MA, Muich SJ, Grant E, Miller JP, Storandt M, Morris JC. The AD8: A brief informant interview to detect dementia. Neurology 2005;65:559-564.

Burns JM, Galvin JE, Roe CM, Morris JC, McKeel DW. The substantia nigra in Alzheimer’s disease with extrapyramidal signs. Neurology 2005;64:1397-403.

Roe CM, Behrens MI, Xiong C, Miller JP, Morris JC. Alzheimer’s disease and cancer.  Neurology 2005;64:895-898.

Shah K, Carr DB, Roe CM, Miller JP, Coats M, Morris JC. Impaired physical performance and the assessment of Dementia of the Alzheimer’s Type. Alzheimer Disease and Associated Disorders 2004;18:112-119.

Pastor P, Roe CM, Villegas A, Bedoya G, Chakraverty S, García G, Tirado V, Norton J, Ríos S, Martínez M, Kosik K, Lopera F, Goate AM. APOE Є4 modifies age of onset in a large E280A PS1 Alzheimer’s Disease kindred. Annals of Neurology 2003;54:163-169.

Duchek JM, Carr DB, Hunt L, Roe CM, Xiong C, Shah K, Morris JC. Longitudinal Driving Performance in Early-Stage Dementia of the Alzheimer Type.  Journal of the American Geriatrics Society 2003; 51:1342-1347.